References
Infectious disease
Hepatitis C
Description: Epidemiological online data collection on HCV prevalence and genotyping of patients with immigrant background.
Services: Incorporation of historical data into an existing web-based study environment, data analysis, hosting.
QuoMedic/ Medeora Project
Description: Online treatment study of the safety and efficacy of pegylated interferon (PegIFN alpha-2b) and ribavirin in the treatment of chronic hepatitis C (cHC).
Services: Incorporation of historical data into an existing web-based study environment, data analysis, hosting.
QuoMedic/ Medeora Project
Description: Development of a hepatitis database that allows the clinician to document data of hepatitis B and C infected patients.
Services: Consulting and planning. Development of a web-based database software to document the clinical data of hepatitis B and C infected patients using standard medical catalogs. Evaluation of the collected data in real time.
QuoMedic/ Medeora Project
When facing a knowledgeable patient population that is constantly searching for the latest treatment information on hepatitis C, the key has been to be as up front and direct as possible. By creating detailed-yet-accessible recruitment and retention materials, BBK has provided support, empathy, and care to participants struggling with this disease.
BBK Worldwide Project
Human Immunodeficiency Virus (HIV)
Description: Each therapy involves hidden costs. The aim of the study of health care costs was to collect, calculate and evaluate the treatment costs of HIV infection in the German health care system.
Prospective non-interventional study with electronic data acquisition via interfaces to HIS etc. and accompanying patient survey on quality of life. The questionnaires were converted to a digital format and integrated into the overall data set.
Services: Consulting services during the design and planning of the study, programming the online application, hosting, reporting, support of participants, contract and fee processing.
QuoMedic/ Medeora Project
Description: Development of a free database for documentation of complex medical documentation in HIV-infected patients.
Services: Development of software to supplement the computer software in doctor’s practices, with the following features: graphical analysis of CD4 cell measurements and HIV viral load for trend analysis of key parameters. Possibility to document adverse effects of antiretroviral drugs and drug resistance, drug levels and hepatitis serology. Function for automatic doctor’s letter, interface to physician-user systems and the HIV Competence Network (funded by the federal government) and the Robert Koch Institute (Berlin).
A non-profit project of Medeora
Description: Observation of viremic HIV-infected patients receiving antiretroviral therapy in a retrospective epidemiological setting. The aim of this study was to show how many patients receiving [HA] ART have a detectable viral load, what the reasons are and how these patients are treated. The study was designed to help clarify the prevalence of these patients in Germany and to document the reasons for the inadequate response of the [HA] ART.
Services: Consulting services during the design and planning of the study, programming the online application, hosting, reporting, support of participants, contract and fee processing.
QuoMedic/ Medeora Project
Description: Treatment study on the tolerability, quality of life and efficacy of darunavir/r in HIV-infected patients.
Services: Consulting services during the design and planning of the study, programming the online application, hosting, reporting, support of participants, contract and fee processing.
QuoMedic/ Medeora Project
If there’s any good news about fighting HIV, it’s that sponsors are working hard to rapidly increase the arsenal of treatment options. The bad news is that as a result, the HIV clinical study marketplace is very crowded. BBK has responded by creating campaigns for HIV studies that cut through clutter while being culturally adaptable.
BBK Worldwide Project
Nosocomial pneumonia
To meet the challenges of recruiting studies for nosocomial pneumonia, BBK has worked closely with physicians and site staff to develop sitespecific recruitment plans. Based on each site’s needs, BBK created customized recruitment and/or retention toolkits that help facilitate on-time enrollment.
BBK Worldwide Project
Human Papillomavirus (HPV)
Because people with HPV are often asymptomatic, BBK’s public relations team has frequently worked with infectious disease centers and dedicated study sites to promote HPV-related clinical trials using intra-institutional press releases and educational forums. Our methods have encouraged discussion about the disease, best practices, and the latest in research.
BBK Worldwide Project
Chronic bronchitis
For campaigns involving seasonal infections, BBK generally faces one of two challenges: enrolling a study months before a condition typically presents itself, or towards the end of a given season when disease cases are on the decline. In either case, BBK has created radio and TV ads that have consistently generated the right type of patient referrals.
BBK Worldwide Project
Molluscum Contagiosum
Warts can be an embarrassing condition. Faced with this challenge of competing with overthe- counter medications, BBK reached out to referring physicians directly to obtain pediatric referrals necessary for enrollment. Furthermore, BBK’s toolkits have been effective in dispelling myths surrounding both the origin and treatment of this stubborn virus.
BBK Worldwide Project
Microbiology
Staphylococcus Bacteremia
Description: One of the largest prospective, multicenter studies in the world for the study of catheter-related staphylococcemia. The challenge was to provide a documentation environment in no time at all that could not only safely and reliably capture and store more than a thousand variables, but would also allow for simultaneous documentation by half a dozen centers and a central evaluation.
Services: Consultation and planning. Development of a web-based database software for the documentation of staphylococcemia.
QuoMedic/ Medeora Project
Virology
Respiratory viruses
Description: Multicenter, web-based project on the prevalence of viral diseases of the respiratory tract with central evaluation of all documented infections in real time. International project, 55 centers, app. 260,000 documented tests (as of November 2016), online application.
Services: Consultation during the design and planning of the study, programming of online application, hosting, reporting, support of participants.
QuoMedic/ Medeora Project
Oncology
Breast cancer
BBK has enrolled numerous breast cancer studies, including studies of what is now the leading first-line therapy for early-stage breast cancer. Our key to recruitment success has been facilitating the discussion of study participation between physician and patient, at the moment when doctors are often disinclined to bring up clinical studies.
BBK Worldwide Project
Melanoma
BBK has conducted U.S.- and global-based adaptive patient recruitment and retention campaigns, as well as enrollment feasibility analyses and site selections for all phases of melanoma studies. Leveraging our expertise in educating patients, our campaigns inform patient audiences about this disease while positioning the study as an option worthy of consideration.
BBK Worldwide Project
Colorectal cancer
Clinical studies of colorectal cancer are best served by BBK’s comprehensive advertising and public relations initiatives. These tactics are an invaluable means of conveying a balance of empathetic images and disarming messages – a balance that drives study participation and encourage preventative care, especially among older patients.
BBK Worldwide Project
Prostate cancer
BBK has extensive experience supporting prostate cancer studies in all phases and throughout the world. From detection to endstage diagnoses, BBK has created empathetic, straightforward patient materials, engaging physician-to-physician tactics, and a customized level of site support to ensure on-time study enrollment.
BBK Worldwide Project
Head and neck cancers
Because of the extremely low incidence of head and neck cancers, international studies face significant enrollment challenges. When this has occurred, BBK’s physician referral programs have provided breakthrough combinations of wellplanned, country-by-country implementations, and highly differentiating study brands.
BBK Worldwide Project
Early breast cancer
Powerful messages of encouragement can be the key to coaching women with early breast cancer to aggressively pursue all treatment options – including study participation. The value of deploying these pragmatic messages is evident in the overwhelming success of BBK enrolling these types of studies and in the branding of approved treatments.
BBK Worldwide Project
Urology
Overactive Bladder (OAB)
Facing aggressive enrollment targets and hard-to-reach patient audiences is nothing new for overactive bladder studies. In a number of global and U.S.-based studies, BBK has worked to mitigate these challenges through effective messaging and leveraged online media to drive recruitment success and significantly boost patient referrals.
BBK Worldwide Project
Menopause and vaginal atrophy
Considering the subject, it’s understandable that vaginal dryness and atrophy are frequently untreated – though not untreatable – symptoms of menopause. That’s why BBK’s campaigns to support studies in this area have taken a pragmatic, direct, and mature tone that wins the confidence of and is appreciated by study participants.
BBK Worldwide Project
Benign Prostatic Hyperlapsia (BPH)
BBK has conducted numerous adaptive patient recruitment and product marketing studies for BPH. Because the topic is men’s sexual health, programs must strike the right balance between sensitivity and frank discussion. Just as important, these campaigns must take into account patients’ concerns about cancer, if they are not yet diagnosed.
BBK Worldwide Project
Nephrology
Kidney disease
Description: prospective register to evaluate the course of disease in patients with coronary heart disease (CHD) and chronic kidney disease as a basis for therapeutic approaches.
Services: Receipt of medical study data (from a proprietary system) in electronic form and integration of this data into an existing study Environment.
QuoMedic/ Medeora Project
The many studies supported by BBK involving conditions of the kidney have focused largely on end-stage renal disease. Our campaigns have addressed the difficulties of consenting older patients who have few treatment options by training study staff to guide these patients through the typically lengthy and requirement-heavy participation period.
BBK Worldwide Project
Cardiovascular disease in children with kidney disease
Description: Study to evaluate heart and vascular disease in children with chronic kidney disease.
Services: Receipt of medical study data (from a proprietary system) in electronic form and integration of this data into an existing study environment.
QuoMedic/ Medeora Project
Kidney disease: Cohort Study
Description: National cohort study of chronic kidney disease. The aim of this study is to find out more about the development of diabetic kidney disease by means of a regular, thorough examination of several thousand diabetics.
Services: Consultation on the conceptual design of the study, programming of the online application, support of participants. Implementation of the generic data protection concept B of TMF - Technologie- und Methodenplattform für die vernetzte medizinische Forschung e. V (TMF Association for Technology and Methodological Platforms for Networked Medical Research) to adequately pseudonymize patient data under privacy laws.
QuoMedic/ Medeora Project
Kidney disease in old age
Description: Study on the epidemiology of chronic renal failure in people over 70.
Services: Consultation on the conceptual design of the study, programming of the online application, support of participants. Implementation of the generic data protection concept B of TMF - Technologie- und Methodenplattform für die vernetzte medizinische Forschung e. V (TMF Association for Technology and Methodological Platforms for Networked Medical Research) to adequately pseudonymize patient data under privacy laws.
QuoMedic/ Medeora Project
Kidney disease and type 2 diabetes mellitus
Description: Study to investigate the possible causes of renal involvement in patients with type 2 diabetes mellitus.
Services: Receipt of medical study data (from a proprietary system) in electronic form and integration of this data into an existing study environment.
QuoMedic/ Medeora Project
Dialysis
Description: Market research study in which quantitative and qualitative methods were used. The aim of the study was to clarify the question what it is that motivates people to donate blood, and why they continue donating blood.
Services: Consultation and planning of the study, development of an online questionnaire, implementation of qualitative interviews, data evaluation, presentation of results.
QuoMedic/ Medeora Project
Focal Segmental Glomerulosclerosis (FSGS)
For multinational studies of rare conditions like FSGS, sponsors rely on BBK to help determine the feasibility of achieving patient enrollment within a certain time frame – or at all. Our unparalleled market research methods and techniques extrapolate the critical data necessary for informed decision-making early in the planning process.
BBK Worldwide Project
Central Nervous System
Psychiatric conditions
Conditions like schizophrenia, bipolar disorder, depression, and addiction are insidious and overwhelming, take many forms, and strike all ages and cultures. Over many years and across many studies, BBK has created compassionate and compelling campaigns that achieve enrollment by helping patients to understand their options.
BBK Worldwide Project
Depression
Description: In a global clinical placebo-controlled research study on major depressive disorder (MDD), a drug under test, taken by patients together with the antidepressant known to them (SSRIs), was evaluated. The efficacy of the drug was observed over a period of 17 weeks.
Services: Media planning for the participating European countries with respect to print, radio and billboard advertising, media selection, and their complete order and financial management. Management of the central call center.
QuoMedic/ Medeora Project
Epilepsy
Description: A clinical study to evaluate a new drug that was developed for better control of epileptic seizures. In this placebo-controlled study, patients were observed over a period of 26 weeks in 2 different study groups.
Services: Implementation of multi-lingual webinars with participating clinics.
QuoMedic/ Medeora Project
BBK has successfully supported numerous epilepsy studies. We have also conducted a wide range of market research to determine study feasibility and country and site selection. Our campaigns have achieved enrollment by using a variety of tactics, tailored to the needs of the protocol and to the target patient.
BBK Worldwide Project
Multiple Sclerosis (MS)
Across all stages of MS, BBK has successfully supported many studies for this condition with care, concern, and creativity. Communications meet patients at their stage of disease, helping them to consider not only the potential benefits of participation in a particular study, but also the long-term approach to their care.
BBK Worldwide Project
Migraine
BBK has conducted many campaigns – both adaptive patient recruitment and public health awareness – to help bring new migraine treatments to market and to raise migraine to the level of a legitimate medical condition. Our work in this area reflects the importance of understanding the patients’ experience and their motivations.
BBK Worldwide Project
Alzheimer’s disease
Because Alzheimer’s renders many patients incapable of providing informed consent, BBK’s recruitment programs have focused on supporting and informing caregivers just as much as patients. Appreciative feedback from caregivers, the patients in their care, and sites has reflected the resonance of our messaging.
BBK Worldwide Project
Dyslexia
In the early planning stages of international dyslexia studies, BBK’s multicountry market research assessments have helped define both the ideal investigator specialty and the parameters of the condition for each nation. The results of these assessments assist sponsor clinical teams in selecting countries and sites, and in planning recruitment support.
BBK Worldwide Project
Pneumology
Asthma
BBK has supported numerous asthma studies for many pharmacological and medical device innovations – inhalers, capsules, injections, and more. The one common denominator: patients want to participate in daily activities with a minimum of management. With this in mind, BBK’s campaigns have helped patients to consider a study as part of their treatment plan.
BBK Worldwide Project
Mild allergic asthma
To identify specific patient populations with seasonal allergies, BBK relies on GeoPopulation AnalyzerSM: our state-of-the-art, proprietary technology that helps drive our country, site location, and recruitment outreach media selections. This resource allows BBK to efficiently implement custom media plans on a site-by-site basis to drive enrollment.
BBK Worldwide Project
Chronic bronchitis
For campaigns involving seasonal infections, BBK generally faces one of two challenges: enrolling a study months before a condition typically presents itself, or towards the end of a given season when disease cases are on the decline. In either case, BBK has created radio and TV ads that have consistently generated the right type of patient referrals.
BBK Worldwide Project
Grass pollen allergies
BBK has extensive experience supporting studies designed to reduce the effects of grass pollen in children and adults. Intensive market research and focus-group testing have both driven the development of creative materials and advertising that BBK has used to support the enrollment of studies of investigational drugs for grass pollen allergies.
BBK Worldwide Project
Chronic obstructive pulmonary disorder
To improve the current treatments for COPD, BBK has targeted patients and physicians who are particularly interested in advancing future remedies. This approach allows us to quickly cut through informational clutter to engage and motivate participants as well as to generate high-quality referrals.
BBK Worldwide Project
Emphysema
Patients with emphysema are desperate to find a treatment that meets their unique needs. Using intense nationwide advertising and public relations, BBK has been able to introduce clinical studies as a viable treatment option for those looking to maintain a level of independence in their lives, as well as offering a proactive way to manage their health.
BBK Worldwide Project
